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READ THE PASSAGE IN 2 MINUTES AND WRITE DOWN THE KEY WORDS.

Postoperative immune suppression particularly a loss of cell-mediated immunity is commonly seen after surgery due to an increased release of immune suppressing hormones such as catecholamines, prostaglandins and cortisol depending on the amount of surgical stress and tissue damage. Blood transfusion, hypothermia, dehydration and anesthetics can further attenuate immunity . An impaired immunity after surgery is associated with worse outcome, i.e. delayed wound healing, infections, sepsis, multiple-organ failure and cancer recurrence. In particular, postoperative immunosuppression comprises decreased numbers of natural killer (NK) cells, T lymphocytes, as well as an impaired function of T lymphocytes and monocytes including a suppressed expression of human leukocyte antigen-D related on monocytes (mHLA-DR) . B lymphocytes seem to be less effected . Furthermore, increasing numbers of T regulatory (Treg) cells and neutrophils often occur after surgery . While major surgery may suppress cellular immunity for several days, humoral immunity remains relatively intact . However, the recovery of immune cells focusing on differences between innate and acquired immunity during severe postoperative immunosuppression has not been investigated, yet.

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  1. UnknownJune 11, 2021 at 12:24 PM

    Cell mediated immunity suppression after sugery, and various therapies

    Reasons for suppressed immunity following surgery

    Cellular and humoral immunity in relation with surgery

    ReplyDelete

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