Curative treatment for alcohol-promoted cirrhosis is currently limited to orthotropic liver transplantation. However, a global shortage of donor organs has resulted in the death of patients on the organ waitlist . Therefore, stem cell-based therapy has emerged as a promising alternative with accumulating evidence of its efficacy in experimental and clinical studies. Adult stem cells have been isolated from the bone marrow and identified as mesenchymal stem cells (MSCs). The self-renewal and differentiation abilities of these cells are of great interest in cell-based therapies . Alternate sources of MSCs, such as umbilical cord tissue, blood, liver, dental pulp, and skin, have been investigated; the functions of MSCs depend on the collection procedure, cell quantity, immaturity, and cell profile . MSCs originating from different sources are known to play a role in healing and repairing damaged tissues through secreted cytokines.
.
Comments
Post a Comment