OET4U

 

  Strategies to survive severe infection ICU patients with sepsis often present dramatically different outcomes despite having had a similar initiating pathogen or pathogen load, or even having completely eliminated the original infection. The contrasting outcomes may be explained by the need for two different but interdependent and evolutionarily conserved defense strategies to survive a severe infection: resistance, which relies on effector mechanisms to reduce pathogen load, and disease tolerance, which provides host tissue damage control and limits disease severity irrespective of pathogen load . Research on the initiation of protective immune responses has so far mostly focused on the direct sensing of microorganisms via pattern recognition receptors (PRRs). The pattern-triggered immunity model states that PRRs recognize microorganism-associated molecular patterns (MAMPs) representative of different groups of microorganisms, which leads to the activation of effector mechanisms...

 

  Agoraphobia The lifetime prevalence of the common psychological problem known as panic disorder is between 1% and 5%.Panic disorder is characterised by recurrent and unexpected panic attacks associated with several comorbid psychiatric and non-psychiatric conditions such as anxiety, depression, and cardiovascular diseases and impairment of social, work, and family functioning. Agoraphobia is a strong fear or anxiety provoked by real or anticipated exposure to a wide range of situations and is often associated with panic disorder. Successive revisions of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III, DSM-III-R, and DSM-IV) provide similar definitions of panic disorder, refined with each new edition; but in the fifth revision (DSM-5) panic disorder and agoraphobia have been defined individually. Q.Paragraph is about. about the difference between agoraphobia and panic attack. About how DSM will define  About the separate definition of agoraphobia.