OET READING PART B SET 3 Q1

1-Zidovudine

Nausea is another common side effect that may be present in early zidovudine use. Other side effects zidovudine may include granulocytopenia, myopathy, lactic acidosis, hepatomegaly with steatosis, headache.Myopathy may occur within 6–12 months of initiating zidovudine, and has an insidious onset that involves proximal muscle weakness and exercise-induced myalgias. The mechanism of myopathy is believed to be mitochondrial toxicity within myocytes. Zidovudine should be used with caution in patients who have anemia (hemoglobin less than 9.5 grams/deciliter). Reduction of hemoglobin may occur as early as 2 to 4 weeks. Severe anemia may require dose adjustment, discontinuation, and/or blood transfusions. Doses should be reduced until bone marrow recovers if the anemia is significant (hemoglobin less than 7.5 grams/deciliter or reduction of greater than 25% of baseline).

5 Zidovudine can;

   A) Increase decrease of lactate.

   B) Lead to fatty change

   C) Be used for treating anemia