1-Zidovudine
Nausea is another common side effect that may be
present in early zidovudine use. Other side effects zidovudine may include
granulocytopenia, myopathy, lactic acidosis, hepatomegaly with steatosis,
headache.Myopathy may occur within 6–12 months of initiating zidovudine, and
has an insidious onset that involves proximal muscle weakness and
exercise-induced myalgias. The mechanism of myopathy is believed to be mitochondrial
toxicity within myocytes. Zidovudine should be used with caution in patients
who have anemia (hemoglobin less than 9.5 grams/deciliter). Reduction of
hemoglobin may occur as early as 2 to 4 weeks. Severe anemia may require dose
adjustment, discontinuation, and/or blood transfusions. Doses should be reduced
until bone marrow recovers if the anemia is significant (hemoglobin less than
7.5 grams/deciliter or reduction of greater than 25% of baseline).
5 Zidovudine can;
A) Increase
decrease of lactate.
B) Lead
to fatty change
C) Be
used for treating anemia
B
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